Tutorial of numerical continuation and bifurcation theory for systems and synthetic biology

Mathematical modelling allows us to concisely describe fundamental principles in biology. Analysis of models can help to both explain known phenomena, and predict the existence of new, unseen behaviours. Model analysis is often a complex task, such that we have little choice but to approach the problem with computational methods. Numerical continuation is a computational method for analysing the dynamics of nonlinear models by algorithmically detecting bifurcations. Here we aim to promote the use of numerical continuation tools by providing an introduction to nonlinear dynamics and numerical bifurcation analysis. Many numerical continuation packages are available, covering a wide range of system classes; a review of these packages is provided, to help both new and experienced practitioners in choosing the appropriate software tools for their needs.Comment: 14 pages, 2 figures, 2 table

Nonlinear normal modes, modal interactions and isolated resonance curves

The objective of the present study is to explore the connection between the nonlinear normal modes of an undamped and unforced nonlinear system and the isolated resonance curves that may appear in the damped response of the forced system. To this end, an energy balancing technique is used to predict the amplitude of the harmonic forcing that is necessary to excite a specific nonlinear normal mode. A cantilever beam with a nonlinear spring at its tip serves to illustrate the developments. The practical implications of isolated resonance curves are also discussed by computing the beam response to sine sweep excitations of increasing amplitudes.Comment: Journal pape

Nonlinear Modal Analysis of the SmallSat Spacecraft

Non-linear elements are present in practically all spacecraft structures. When such non-linear effects are important linear modal analysis can no longer be applied. The development of a non-linear analogue of linear modal analysis is therefore an important endeavor. The objective of this paper is to show that nonlinear normal modes (NNMs) represent a useful and practical tool in this context. A full-scale spacecraft structure is considered and is modeled using the finite element method. Its NNMs are computed using advanced numerical algorithms, and the resulting dynamics is then carefully analyzed. Nonlinear phenomena with no linear counterpart including nonlinear modal interactions are also highlighted